Composite material for veterinary purposes based on modified starch
DOI:
https://doi.org/10.33216/1998-7927-2025-294-8-58-65Keywords:
modified polysaccharides, active pharmaceutical ingredient, composite material, polyvinyl alcohol, starch, rheology, xeroformAbstract
The article considers the development of veterinary composite materials based on modified starch with the aim of creating new antimicrobial film carriers for transdermal therapeutic systems. The research methodology involved the chemical modification of potato starch with citric and lactic acids under various conditions, followed by its combination with polyvinyl alcohol and xeroform as an active pharmaceutical ingredient. The rheological properties of the resulting compositions were studied by rotational viscometry. It was established that all developed solutions exhibit pseudoplastic properties (n<1) and are characterized by a decrease in viscosity with an increasing shear rate. It was proven that citric acid, due to its multifunctionality, promotes the formation of a covalently cross-linked network structure, which leads to an increase in the viscosity of the solutions. In contrast, lactic acid, having only one carboxyl group, proved to be less effective for intermolecular cross-linking and in some cases catalyzed the partial hydrolysis of starch. The results confirm that the viscosity of the compositions significantly increases with an increase in polyvinyl alcohol content and upon the addition of xeroform, especially for mixtures based on lactic acid-modified starch. Additionally, the kinetic and capacitive characteristics of the adsorption of methylene blue (MB) as a model contaminant were studied. It was found that films with a high content of modified starch, in particular those modified with lactic acid, demonstrate high sorption capacity. This indicates the promising use of the developed materials not only for the retention of medicinal substances, but also for the effective cleaning of the wound bed from exudate and toxic compounds, which is a key factor in accelerated wound healing. The obtained data demonstrate the prospects of using the developed materials for creating effective agents for treating skin damage in veterinary medicine.
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